| ADP | Player | Tier | Bye Week | Years Pro | Salary | Points | Madden | Injury |
| 15.00 | QB Patrick Mahomes II | QB | 10 | 6 | $227,000,000 | 0 | 95/100 | 96/100 |
| 22.00 | QB Josh Allen | QB | 13 | 5 | $222,000,000 | 0 | 92/100 | 96/100 |
| 27.00 | RB Rhamondre Stevenson | RB | 11 | 2 | $3,490,000 | 0 | 73/100 | 89/100 |
| 28.00 | RB Najee Harris | RB | 6 | 2 | $6,200,000 | 0 | 85/100 | 95/100 |
| 31.00 | RB Travis Etienne Jr. | RB | 9 | 0 | TBD | TBD | ||
| 32.00 | WR DK Metcalf | WR | 5 | 0 | TBD | TBD | ||
| 34.00 | RB Joe Mixon | RB | 7 | 6 | $30,300,000 | 0 | 93/100 | 92/100 |
| 35.00 | RB Jahmyr Gibbs | RB | 9 | 0 | TBD | TBD | ||
| 38.00 | WR Deebo Samuel | WR | 9 | 4 | $5,850,000 | 0 | 89/100 | 88/100 |
| 39.00 | RB Aaron Jones | RB | 6 | 6 | $35,000,000 | 0 | 89/100 | 86/100 |
| 41.00 | WR Amari Cooper | WR | 5 | 8 | $41,120,000 | 0 | 90/100 | 87/100 |
| 43.00 | WR Keenan Allen | WR | 5 | 10 | $59,600,000 | 0 | 91/100 | 87/100 |