Rankings Updated: Monday, May 3, 2021 @ 10:26 AM EST
| Rank | Player | Points | Opp. | Game Time | Status |
| 1 | RB Derrick Henry | + 20 | @ HOU | Sunday 1:00 PM | |
| 2 | RB Jonathan Taylor | + 18 | vs JAC | Sunday 1:00 PM | |
| 3 | RB Nick Chubb | + 15 | vs PIT | Sunday 1:00 PM | |
| 4 | RB David Montgomery | + 17 | vs GB | Sunday 1:00 PM | |
| 5 | RB Austin Ekeler | + 19 | @ KC | Sunday 4:25 PM | |
| 6 | RB Aaron Jones | + 16 | @ CHI | Sunday 8:20 PM | |
| 7 | RB Melvin Gordon | + 15 | vs LV | Sunday 4:05 PM | |
| 8 | RB Josh Jacobs | + 15 | @ DEN | Sunday 8:20 PM | |
| 9 | RB D'Andre Swift | + 16 | vs MIN | Thursday 12:30 PM | |
| 10 | RB Chris Carson | + 15 | @ SF | Sunday 4:05 PM | |
| 11 | RB Myles Gaskin | + 16 | @ BUF | Sunday 1:00 PM | |
| 12 | RB Jeff Wilson | + 14 | vs SEA | Monday 8:15 PM | |
| 13 | RB David Johnson | + 15 | vs TEN | Sunday 1:00 PM | |
| 14 | RB Ezekiel Elliott | + 15 | @ NYG | Thursday 4:30 PM | |
| 15 | RB Alexander Mattison | + 13 | @ DET | Sunday 1:00 PM | |
| 16 | RB Antonio Gibson | + 14 | @ PHI | Sunday 1:00 PM | Did Not Practice On Friday. Questionable For Week 17 At Philadelphia (Toe) |
| 17 | RB JK Dobbins | + 12 | @ CIN | Sunday 1:00 PM | |
| 18 | RB Ronald Jones | + 12 | vs ATL | Sunday 4:25 PM | |
| 19 | RB Kenyan Drake | + 11 | @ LAR | Sunday 4:05 PM | |
| 20 | RB Ty Johnson | + 12 | @ NE | Sunday 1:00 PM | |
| 21 | RB Wayne Gallman | + 11 | vs DAL | Sunday 1:00 PM | |
| 22 | RB Kareem Hunt | + 12 | vs PIT | Sunday 1:00 PM | |
| 23 | RB Giovani Bernard | + 12 | vs BAL | Sunday 1:00 PM | |
| 24 | RB Nyheim Hines | + 12 | vs JAC | Sunday 1:00 PM | |
| 25 | RB Dare Ogunbowale | + 11 | @ IND | Sunday 1:00 PM | |
| 26 | RB Ty Montgomery | + 12 | @ CAR | Sunday 1:00 PM | |
| 27 | RB Boston Scott | + 11 | vs WAS | Monday 8:15 PM | |
| 28 | RB Malcolm Brown | + 10 | vs ARI | Sunday 4:05 PM | |
| 29 | RB J.D. McKissic | + 13 | @ PHI | Sunday 1:00 PM | |
| 30 | RB Gus Edwards | + 9 | @ CIN | Sunday 1:00 PM | Limited Practice On Friday. Questionable For Week 17 At Cincinnati (Back) |
| 31 | RB Sony Michel | + 8 | vs NYJ | Sunday 1:00 PM | |
| 32 | RB Rodney Smith | + 9 | vs NO | Sunday 1:00 PM | |
| 33 | RB James Conner | + 9 | @ CLE | Monday 5:00 PM | |
| 34 | RB Devin Singletary | + 9 | vs MIA | Sunday 1:00 PM | |
| 35 | RB Tony Pollard | + 9 | @ NYG | Thursday 4:30 PM | |
| 36 | RB Ito Smith | + 8 | @ TB | Sunday 1:00 PM | |
| 37 | RB Darwin Thompson | + 8 | vs LAC | Thursday 8:20 PM | |
| 38 | RB Cam Akers | + 7 | vs ARI | Sunday 4:05 PM | Limited Practice On Friday. Questionable For Week 17 Vs. Arizona (Ankle) |
| 39 | RB Zack Moss | + 7 | vs MIA | Sunday 1:00 PM | |
| 40 | RB Chase Edmonds | + 8 | @ LAR | Sunday 4:05 PM | Did Not Practice On Friday. Questionable For Week 17 At L.a. Rams (Hip) |
| 41 | RB James White | + 9 | vs NYJ | Sunday 1:00 PM | |
| 42 | RB Leonard Fournette | + 7 | vs ATL | Sunday 4:25 PM | |
| 43 | RB Darrel Williams | + 7 | vs LAC | Thursday 8:20 PM | |
| 44 | RB Samaje Perine | + 6 | vs BAL | Sunday 1:00 PM | |
| 45 | RB Jamaal Williams | + 7 | @ CHI | Sunday 8:20 PM | |
| 46 | RB Mike Boone | + 5 | @ DET | Sunday 1:00 PM | |
| 47 | RB Todd Gurley | + 6 | @ TB | Sunday 1:00 PM | |
| 48 | RB Kalen Ballage | + 6 | @ KC | Sunday 4:25 PM | |
| 49 | RB Devontae Booker | + 5 | @ DEN | Sunday 8:20 PM | |
| 50 | RB Tony Jones Jr | + 5 | @ CAR | Sunday 1:00 PM | |
| 51 | RB Ameer Abdullah | + 5 | @ DET | Sunday 1:00 PM | |
| 52 | RB Adrian Peterson | + 4 | vs MIN | Thursday 12:30 PM | |
| 53 | RB Salvon Ahmed | + 5 | @ BUF | Sunday 1:00 PM | |
| 54 | RB Rashaad Penny | + 5 | @ SF | Sunday 4:05 PM | |
| 55 | RB Josh Adams | + 4 | @ NE | Sunday 1:00 PM | |
| 56 | RB Benny Snell Jr | + 4 | @ CLE | Monday 5:00 PM | |
| 57 | RB Devine Ozigbo | + 5 | @ IND | Sunday 1:00 PM | |
| 58 | RB Alfred Morris | + 4 | vs DAL | Sunday 1:00 PM | |
| 59 | RB Le'Veon Bell | + 5 | vs LAC | Thursday 8:20 PM | Limited Practice On Friday. Questionable For Week 17 Vs. L.a. Chargers (Knee) |
| 60 | RB Brian Hill | + 5 | @ TB | Sunday 1:00 PM | |
| 61 | RB Jerick McKinnon | + 6 | vs SEA | Monday 8:15 PM | |
| 62 | RB JJ Taylor | + 4 | vs NYJ | Sunday 1:00 PM | |
| 63 | RB Royce Freeman | + 5 | vs LV | Sunday 4:05 PM | |
| 64 | RB Darrynton Evans | + 4 | @ HOU | Sunday 1:00 PM | |
| 65 | RB AJ Dillon | + 3 | @ CHI | Sunday 8:20 PM | |
| 66 | RB Trenton Cannon | + 4 | vs NO | Sunday 1:00 PM | |
| 67 | RB Kyle Juszczyk | + 5 | vs SEA | Monday 8:15 PM | |
| 68 | RB Ke'Shawn Vaughn | + 3 | vs ATL | Sunday 4:25 PM | |
| 69 | RB Dion Lewis | + 3 | vs DAL | Sunday 1:00 PM | |
| 70 | RB Kerryon Johnson | + 3 | vs MIN | Thursday 12:30 PM | |
| 71 | RB Tevin Coleman | + 3 | vs SEA | Monday 8:15 PM | |
| 72 | RB Jordan Howard | + 3 | vs WAS | Monday 8:15 PM | |
| 73 | RB Justin Jackson | + 3 | @ KC | Sunday 4:25 PM | |
| 74 | RB Peyton Barber | + 2 | @ PHI | Sunday 1:00 PM | |
| 75 | RB Jordan Wilkins | + 2 | vs JAC | Sunday 1:00 PM | |
| 76 | RB Alex Collins | + 2 | @ SF | Sunday 4:05 PM | |
| 77 | RB Joshua Kelley | + 2 | @ KC | Sunday 4:25 PM | |
| 78 | RB Corey Clement | + 2 | vs WAS | Monday 8:15 PM | |
| 79 | RB Anthony McFarland Jr | + 2 | @ CLE | Monday 5:00 PM | |
| 80 | RB Matt Breida | + 2 | @ BUF | Sunday 1:00 PM | |
| 81 | RB Jeremy McNichols | + 2 | @ HOU | Sunday 1:00 PM | |
| 82 | RB Xavier Jones | + 2 | vs ARI | Sunday 4:05 PM | |
| 83 | RB Mark Ingram | + 1 | @ CIN | Sunday 1:00 PM | Full Practice On Friday. Questionable For Week 17 At Cincinnati (Illness) |
| 84 | RB Jalen Richard | + 2 | @ DEN | Sunday 8:20 PM | Ir. Reserve - Covid-19 (Undisclosed) |
| 85 | RB Latavius Murray | + 1 | @ CAR | Sunday 1:00 PM | Ir. Reserve - Covid-19 (Undisclosed) |
| 86 | RB Trayveon Williams | + 1 | vs BAL | Sunday 1:00 PM | |
| 87 | RB Jaylen Samuels | + 2 | @ CLE | Monday 5:00 PM | |
| 88 | RB Alec Ingold | + 1 | @ DEN | Sunday 8:20 PM | |
| 89 | RB Buddy Howell | + 1 | vs TEN | Sunday 1:00 PM | |
| 90 | RB Ryan Nall | + 1 | vs GB | Sunday 1:00 PM | |
| 91 | RB C.J. Ham | + 1 | @ DET | Sunday 1:00 PM | |
| 92 | RB Theo Riddick | + 1 | @ DEN | Sunday 8:20 PM | |
| 93 | RB Justice Hill | + 1 | @ CIN | Sunday 1:00 PM | |
| 94 | RB Dexter Williams | + 1 | @ CHI | Sunday 8:20 PM | |
| 95 | RB Raymond Calais | + 1 | vs ARI | Sunday 4:05 PM | |
| 96 | RB Artavis Pierce | + 1 | vs GB | Sunday 1:00 PM | |
| 97 | RB Malcolm Perry | + 1 | @ BUF | Sunday 1:00 PM | |
| 98 | RB Javon Leake | + 1 | @ PHI | Sunday 1:00 PM | |
| 99 | RB Patrick Ricard | + 1 | @ CIN | Sunday 1:00 PM | |
| 100 | RB Patrick Laird | + 1 | @ BUF | Sunday 1:00 PM | |
| 101 | RB Jason Huntley | + 1 | vs WAS | Monday 8:15 PM | |
| 102 | RB Jakob Johnson | + 1 | vs NYJ | Sunday 1:00 PM | |
| 103 | RB Dontrell Hilliard | + 1 | vs TEN | Sunday 1:00 PM | |
| 104 | RB LeVante Bellamy | + 0 | vs LV | Sunday 4:05 PM | Full Practice On Friday. Questionable For Week 17 Vs. Las Vegas (Ankle) |
| 105 | RB Alex Armah | + 1 | vs NO | Sunday 1:00 PM | |
| 106 | RB Anthony Sherman | + 0 | vs LAC | Thursday 8:20 PM | |
| 107 | RB Keith Smith | + 1 | @ TB | Sunday 1:00 PM | |
| 108 | RB Travis Homer | + 1 | @ SF | Sunday 4:05 PM | Ir. Injured Reserve (Knee) |
| 109 | RB D'Ernest Johnson | + 0 | vs PIT | Sunday 1:00 PM | |
| 110 | RB Andy Janovich | + 0 | vs PIT | Sunday 1:00 PM | |
| 111 | RB Khari Blasingame | + 0 | @ HOU | Sunday 1:00 PM | Limited Practice On Friday. Questionable For Week 17 At Houston (Ankle) |
| 112 | RB D.J. Foster | + 0 | @ LAR | Sunday 4:05 PM | |
| 113 | RB Gabe Nabers | + 0 | @ KC | Sunday 4:25 PM | |
| 114 | RB Nathan Cottrell | + 0 | @ IND | Sunday 1:00 PM | Limited Practice On Friday. Questionable For Week 17 At Indianapolis (Hip) |
| 115 | RB Austin Walter | + 0 | vs SEA | Monday 8:15 PM | |
| 116 | RB Rico Dowdle | + 0 | @ NYG | Thursday 4:30 PM | |
| 117 | RB Derek Watt | + 0 | @ CLE | Monday 5:00 PM | |
| 118 | RB Scottie Phillips | + 0 | vs TEN | Sunday 1:00 PM | |
| 119 | RB Nick Bellore | + 0 | @ SF | Sunday 4:05 PM | |
| 120 | RB Elijah McGuire | + 0 | vs LAC | Thursday 8:20 PM | |
| 121 | RB Michael Burton | + 0 | @ CAR | Sunday 1:00 PM | Ir. Reserve - Covid-19 (Undisclosed) |
| 122 | RB Devonta Freeman | + 0 | vs MIA | Sunday 1:00 PM | Ir. Injured Reserve. Expected Return - Week 17 (Ankle) |