| ADP | Player | Tier | Bye Week | Years Pro | Salary | Points | Madden | Injury |
| 4.00 | RB Austin Ekeler | RB | 5 | 6 | $11,750,000 | 0 | 88/100 | 88/100 |
| 5.00 | TE Travis Kelce | TE | 10 | 10 | $48,750,000 | 0 | 98/100 | 92/100 |
| 6.00 | WR Cooper Kupp | WR | 10 | 6 | $89,850,000 | 0 | 98/100 | 91/100 |
| 7.00 | WR Tyreek Hill | WR | 10 | 7 | $99,900,000 | 0 | 97/100 | 90/100 |
| 8.00 | RB Saquon Barkley | RB | 13 | 5 | $17,650,000 | 0 | 86/100 | 81/100 |