| Match-up | Day | Time | TV Station | Winner |
| GB vs. ARI | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| CAR vs. ATL | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| MIA vs. BUF | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| ATL vs. CAR | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| SF vs. CHI | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| NYJ vs. CIN | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| PIT vs. CLE | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| MIN vs. DAL | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| PHI vs. DET | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| ARI vs. GB | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| LAR vs. HOU | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| TEN vs. IND | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| SEA vs. JAC | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| NYG vs. KC | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| NE vs. LAC | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| HOU vs. LAR | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| BUF vs. MIA | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| DAL vs. MIN | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| LAC vs. NE | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| TB vs. NO | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| KC vs. NYG | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| CIN vs. NYJ | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| DET vs. PHI | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| CLE vs. PIT | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| JAC vs. SEA | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| CHI vs. SF | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| NO vs. TB | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |
| IND vs. TEN | 10/31/2021 | Sunday 12:00 AM | NFL | TBD |