| Match-up | Day | Time | TV Station | Winner |
| CLE vs. ARI | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| LAC vs. BAL | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| TEN vs. BUF | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| MIN vs. CAR | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| GB vs. CHI | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| DET vs. CIN | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| ARI vs. CLE | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| NE vs. DAL | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| LV vs. DEN | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| CIN vs. DET | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| CHI vs. GB | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| IND vs. HOU | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| HOU vs. IND | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| MIA vs. JAC | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| BAL vs. LAC | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| NYG vs. LAR | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| DEN vs. LV | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| JAC vs. MIA | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| CAR vs. MIN | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| DAL vs. NE | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| LAR vs. NYG | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| TB vs. PHI | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| SEA vs. PIT | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| PIT vs. SEA | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| PHI vs. TB | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |
| BUF vs. TEN | 10/17/2021 | Sunday 12:00 AM | NFL | TBD |