| Match-up | Day | Time | TV Station | Winner |
| JAC vs. ARI | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| JAC vs. ATL | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NYG vs. ATL | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| DET vs. BAL | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| HOU vs. CAR | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CLE vs. CHI | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| PIT vs. CIN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CHI vs. CLE | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| PHI vs. DAL | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NYJ vs. DEN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| BAL vs. DET | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| SF vs. GB | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CAR vs. HOU | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| TEN vs. IND | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| ARI vs. JAC | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| LAC vs. KC | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| KC vs. LAC | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| TB vs. LAR | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| MIA vs. LV | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| LV vs. MIA | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| SEA vs. MIN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NO vs. NE | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NE vs. NO | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| ATL vs. NYG | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| DEN vs. NYJ | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| DAL vs. PHI | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CIN vs. PIT | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| MIN vs. SEA | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| GB vs. SF | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| LAR vs. TB | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| IND vs. TEN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CLE vs. BAL | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NO vs. BUF | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| MIA vs. CAR | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| DET vs. CHI | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| PIT vs. CIN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| BAL vs. CLE | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| LV vs. DAL | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| LAC vs. DEN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CHI vs. DET | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| LAR vs. GB | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NYJ vs. HOU | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| TB vs. IND | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| ATL vs. JAC | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| DEN vs. LAC | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| GB vs. LAR | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| DAL vs. LV | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CAR vs. MIA | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| SF vs. MIN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| TEN vs. NE | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| BUF vs. NO | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| PHI vs. NYG | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| HOU vs. NYJ | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NYG vs. PHI | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| CIN vs. PIT | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| MIN vs. SF | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| IND vs. TB | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |
| NE vs. TEN | 9/26/2021 | Sunday 12:00 AM | NFL | TBD |