| Match-up | Day | Time | TV Station | Winner |
| CAR vs. ARI | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| DAL vs. ATL | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| MIA vs. BAL | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| NYJ vs. BUF | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| ARI vs. CAR | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| NE vs. CLE | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| ATL vs. DAL | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| PHI vs. DEN | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| PIT vs. DET | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| SEA vs. GB | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| JAC vs. IND | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| IND vs. JAC | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| LV vs. KC | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| MIN vs. LAC | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| SF vs. LAR | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| KC vs. LV | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| BAL vs. MIA | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| LAC vs. MIN | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| CLE vs. NE | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| TEN vs. NO | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| BUF vs. NYJ | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| DEN vs. PHI | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| DET vs. PIT | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| GB vs. SEA | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| LAR vs. SF | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |
| NO vs. TEN | 11/14/2021 | Sunday 12:00 AM | NFL | TBD |