| Match-up | Day | Time | TV Station | Winner |
| NO vs. ATL | 12/6/2020 | Sunday 1:00 PM | FOX | NO |
| DET vs. CHI | 12/6/2020 | Sunday 1:00 PM | FOX | DET |
| CLE vs. TEN | 12/6/2020 | Sunday 1:00 PM | CBS | CLE |
| CIN vs. MIA | 12/6/2020 | Sunday 1:00 PM | CBS | MIA |
| JAC vs. MIN | 12/6/2020 | Sunday 1:00 PM | CBS | MIN |
| LV vs. NYJ | 12/6/2020 | Sunday 1:00 PM | CBS | LV |
| IND vs. HOU | 12/6/2020 | Sunday 1:00 PM | CBS | IND |
| LAR vs. ARI | 12/6/2020 | Sunday 4:05 PM | FOX | LAR |
| NYG vs. SEA | 12/6/2020 | Sunday 4:05 PM | FOX | NYG |
| PHI vs. GB | 12/6/2020 | Sunday 4:25 PM | CBS | GB |
| NE vs. LAC | 12/6/2020 | Sunday 4:25 PM | CBS | NE |
| DEN vs. KC | 12/6/2020 | Sunday 8:20 PM | NBC | KC |
| WAS vs. PIT | 12/7/2020 | Monday 5:00 PM | FOX | WAS |
| BUF vs. SF | 12/7/2020 | Monday 8:15 PM | ESPN | BUF |
| DAL vs. BAL | 12/8/2020 | Tuesday 8:05 PM | FOX/NFL | BAL |