| Match-up | Day | Time | TV Station | Winner |
| TEN vs. ARI | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| PHI vs. ATL | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| LV vs. BAL | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| PIT vs. BUF | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| NYJ vs. CAR | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| LAR vs. CHI | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| MIN vs. CIN | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| KC vs. CLE | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| TB vs. DAL | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| NYG vs. DEN | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| SF vs. DET | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| NO vs. GB | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| JAC vs. HOU | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| SEA vs. IND | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| HOU vs. JAC | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| CLE vs. KC | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| CHI vs. LAR | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| BAL vs. LV | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| NE vs. MIA | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| CIN vs. MIN | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| MIA vs. NE | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| GB vs. NO | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| DEN vs. NYG | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| CAR vs. NYJ | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| ATL vs. PHI | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| BUF vs. PIT | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| IND vs. SEA | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| DET vs. SF | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| DAL vs. TB | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |
| ARI vs. TEN | 9/12/2021 | Sunday 12:00 AM | NFL | TBD |